Tofanib 5mg Tablet 10Pcs

✔️ Uses of Tofanib 5mg Tablet

Treats inflammatory conditions such as:

• Rheumatoid Arthritis
• Psoriatic Arthritis
• Ulcerative Colitis
• Ankylosing Spondylitis
• Polyarticular Juvenile Idiopathic Arthritis
• Juvenile Psoriatic Arthritis

✔️ How to use Tofanib 5mg Tablet

• Take Tofanib 5mg Tablet medicine in the dose and duration as advised by your doctor.
• Swallow it as a whole.
• Do not chew, crush or break it.
• Tofanib 5mg tablet may be taken with or without food, but it is better to take it at a fixed time.

✔️ Side effects of Tofanib 5mg Tablet

• Diarrhea
• Headache
• Fever, fatigue
• Swelling of the feet and hands
• High blood pressure
• Cough
• Rash
• High blood pressure
• Shingles (herpes zoster)
• Influenza
• Sinusitis
• Urinary bladder infection
• Sore throat
• Signs of muscle problems
• Stomach pain (possibly due to inflammation of the stomach lining)
• Vomiting, nausea
• Indigestion
• Anaemia
• Nasal congestion (stuffy nose)
• Runny nose
• Upper respiratory tract infection
• Lung infections such as pneumonia or bronchitis
• Nasopharyngitis (infections of the nose, throat, or windpipe)

✔️ Quick Suggestions:

• Tofanib 5mg Tablet is used either by itself or in conjunction with other medications to treat rheumatoid arthritis that did not respond to other anti-rheumatic medications.
  The full effects of Tofanib 5mg Tablet may not be felt for three to six months. Continue taking it as directed.
• Eat food rich in antioxidants & Avoid smoking and alcohol consumption.
  To check on your kidney, liver, blood count, or cholesterol levels, your doctor could order routine blood tests.
• Exercise eliminates joint stiffness and helps muscles get stronger. Swimming or light exercise like strolling for 20 to 30 minutes might be beneficial.
• Yoga practice may also aid with pain management and increase joint flexibility.
• It may be a little more difficult for people to fight against infections when using Tofanib 5mg Tablet. If you have infection-related symptoms such as fever, chills, cough, or aches and pains, let your doctor know.
• Before prescribing this drug, your doctor may do a chest X-ray and a TB (tuberculosis) skin test.
• By engaging in regular, low-stress exercise and eating a balanced diet, you may maintain a healthy weight.
• Get enough sleep since giving your muscles a break might assist to reduce swelling and inflammation.
• If you are expecting a child, intend to become pregnant, or are breastfeeding.

✔️ Indication of Tofanib 5mg Tablet

Tofacitinib is indicated for the treatment of adult patients with moderate to severely active rheumatoid arthritis who have not responded or are intolerant to methotrexate. It can be used alone or in combination with methotrexate or other non-biologically modifying anti-rheumatic medications (DMARDs).

Tofacitinib is indicated for the treatment of adult patients with active psoriatic arthritis who have a poor response or intolerance to methotrexate or other disease-modifying antirheumatic drugs (DMARD).

Tofacitinib is approved for the treatment of adult patients with moderate to severe active ulcerative colitis (UC).

✔️ Pharmacology

Tofacitinib is a JAK inhibitor that is partially reversible and prevents the body from responding to cytokine signals. Tofacitinib prevents STAT phosphorylation and activation by inhibiting JAK. The JAK-STAT signaling pathway regulates cell transcription in hematopoietic and immune cell functions. Tofacitinib works as an anti-inflammatory agent by inhibiting the JAK-STAT pathway. However, there is evidence that it can also have other healing effects.

Rheumatoid arthritis is an autoimmune disease characterized by pro-inflammatory cytokine dysregulation, including IL7, IL15, IL21, IL6, IFN, and IFN. (3) Through the Janus kinase signaling pathway, cytokine signaling promotes the recruitment and activation of immune cells, resulting in tissue inflammation and joint damage.

✔️ Dosage & Administration of Tofanib 5mg Tablet

• Tofacitinib 5mg twice daily or Tofacitinib 11 mg once daily for rheumatoid arthritis. Tofacitinib 5 mg once daily is recommended in patients with moderate to severe renal impairment or moderate Hepatic Impairment.
• Tofacitinib 5mg twice daily or Tofacitinib 11mg once daily for Psoriatic Arthritis (in combination with nonbiologic DMARDs). Tofacitinib 5mg once daily is recommended in patients with moderate to severe Renal Impairment or moderate hepatic impairment.
• Tofacitinib 10mg twice daily for at least 8 weeks, followed by 5 or 10mg twice daily. If an adequate therapeutic benefit is not obtained after 16 weeks of 10 mg twice daily, discontinue. To maintain response, use the lowest effective dose.

✔️ Interaction

• Prior to ingesting Tofanib 5mg Tablet If you are taking any of the following medications, let your doctor know:
• Rifampicin and other antibiotics (used in treating bacterial infections)
  Ketoconazole with fluconazole (used to treat fungal infections)
  Tacrolimus, mercaptopurine, ciclosporin, and azathioprine (medicines that depress the immune system)
• The use of corticosteroids like prednisone (used in treating pain and inflammation)

✔️ Overdosage of Tofanib 5mg Tablet

If you or anyone else unintentionally consumes too much Tofanib 5mg Tablet, call your doctor right away or go to the hospital in the area.

✔️ Contraindications

Hypersensitivity to any of the components of the formulation.

✔️ Pregnancy & Lactation

Pregnancy category C. There are no adequate and well-controlled studies of pregnant women. Tofacitinib should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether tofacitinib is excreted in human milk. Since many drugs are excreted in human milk, and because tofacitinib may have serious adverse reactions to nursing babies, it is necessary to decide whether to stop breastfeeding or the drug, taking into account the importance of the drug for breastfeeding. 

✔️ Precautions & Warnings

• Before starting therapy with Tofanib 5mg Tablet, after 4–8 weeks of treatment, and then every three months, your doctor could advise getting a blood test done to find out your blood cell count.
• Your doctor may recommend routine testing to check your liver and blood cholesterol levels.
• If you develop breathing problems or observe painful skin blisters, let your doctor know.
• Use effective contraception while taking Tofanib 5mg Tablet and for 4 weeks after stopping if you are a woman of childbearing potential.
• If you have serious infections, bloodstream infections, active TB, or severe liver issues like cirrhosis, you should not use Tofanib 5mg Tablet.
• You should also avoid taking it if you have allergies to any of its ingredients.
• If you are trying to get pregnant or are nursing, stay away from Tofanib 5mg Tablet.
• Inform your doctor if you have an infection, symptoms of an infection, a condition that increases your risk of infection, are taking any immune system-altering medications, have or had a history of tuberculosis, liver issues, hepatitis B or C, cancer, are at a high risk of developing skin cancer, inflammation/ulcers of the large intestine, kidney issues, plan to get vaccinated, or have hepatitis A or B, high cholesterol, hypertension, heart stroke, diabetes, or issues with blood clotting.
• Avoid using Tofanib 5mg Tablet if you have low red or white blood cell counts.
• Children under the age of 18 should not use Tofanib 5mg Tablet since its safety and effectiveness have not been proven.
• Before starting therapy with Tofanib 5mg Tablet, after 4–8 weeks of treatment, and then every three months, your doctor could advise getting a blood test done to find out your blood cell count.
• Your doctor may recommend routine testing to check your liver and blood cholesterol levels. To rule out any adverse effects, keep your doctor updated about your medical history and prescriptions.

✔️ Storage Conditions

Store below 30ºC. Protect from light. Keep out of the reach of children.